Jose Altuve's potential tying home run was wiped away when umpire Joe West ruled that fans reaching for the ball interfered with Boston right fielder Mookie Betts as he attempted to make a leaping catch.
Security officials reportedly were on the lookout because they had been warned about suspicious activity by Houston during the ALDS against the Cleveland Indians.
There have been no further updates on Chris Sale's condition so there's no information as to how or if this will impact his spot in the rotation going forward.
Game 2 of the best-of-seven series is Sunday night, with Boston left-hander David Price trying to end his postseason skid against Astros righty Gerrit Cole.